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MODY (maturity onset diabetes of the young)
MODY or ‘maturity onset diabetes of the young’ is a type of diabetes affecting young people. It runs in families and often develops before the age of 25 years.
The main problem relates to the production of insulin by the pancreas.
About 1-2% of people who have diabetes may have MODY.
This condition occurs due to inheriting a defective gene from one’s parents. It is Autosomal Dominant which means that just one of the parrents needs to have the condition in order to pass it on.
If one of the parents has MODY the children will have a 50% chance of inheriting the gene and therfore developing MODY. In other words each child has a 50-50 chance of developing the condition. It is important to recognise that this is a ‘statistical’ estimate of risk. You could have six children and all of them could still be affected and it is equally possible that none are affected.
There are 5 genes which have been identified as causing MODY. The type of MODY inherited will depend on the gene responsible and are labelled as MODY 1 to MODY 5.
The 5 genes identified are:
- To decide on appropriate treatment.
- Knowing the type of MODY will help predict how diabetes is going to progress.
- To advise other family members on risk of inheriting the condition and passing it on.
Just like type 2 diabetes with diet and exercise. Sometimes, tablets or insulin are required.
Ó Dr Nishan Wijenaike, Consultant Physician
West Suffolk Diabetes Service
28th August 2003