Type 1 diabetes, previously known as insulin-dependent diabetes or juvenile diabetes is usually encountered in children and young adults.
Insulin is a hormone (chemical messenger) which is produced by the beta cells of the pancreas. It is this hormone which helps move glucose into the cells of the body. Without insulin we cannot utilize glucose effectively and blood sugar levels increase. The excess blood sugar spills over into the urine and is lost. An increased volume of fluid is also lost resulting in the typical symptoms of thirst and increased passage of urine. You lose weight due to inability to absorb sugars and progressive weakness ensues. Patients with type 1 diabetes are dependent on insulin for survival hence the term 'insulin dependent' diabetes.
In type 1 diabetes beta cells of the pancreas are gradually destroyed by a process called 'autoimmune disease'. The immune system fails to recognise the beta cells as part of your body and attacks them. When the number of functioning beta cells dwindle eventually, your pancreas is unable to produce insulin and diabetes develops.
Over a long period of time, high levels of sugar in the blood can cause permanent damage to the eyes, nerves and kidneys. Long standing diabetes also does damage to blood vessels resulting in heart attacks and strokes. Controlling your sugar levels and regular monitoring of your condition can prevent many of these complications. People with type 1 diabetes can lead happy healthy lives by taking good care of their blood sugar.
Type 1 diabetes often develops rapidly, and the following symptoms may appear within weeks:
Finding out you have diabetes can be a frightening experience. Type 1 diabetes can be fatal if not treated with insulin. Most patients lead relatively normal lives with insulin therapy. However the normal life span is reduced by approximately five years by a diagnosis of type 1 diabetes.
There are three emergencies that occur with type 1 diabetes.
Diabetic Ketoacidosis is a life threatening complication which occurs in people with type 1 diabetes. It occurs due to a variety of factors ranging from infections and stress to either deliberately or un-intentionally neglecting to take one's dose of insulin. Due to lack of insulin there is a rapid breakdown of fat, forming acidic chemicals called ketone bodies. This condition is described in detail on a separate page.
Hypoglycaemia does not occur due to diabetes but rather as a complication of its treatment.
The long term complications of type 1 diabetes are believed to be related to persistently high levels of blood sugar. Complications may involve the eyes, kidneys and nerves and are described in detail in other sections.
Statistics tell us that 8 out of 10 people with type 1 diabetes have no other family members affected. The remaining two would have at least one family member with diabetes. If your mother or father has diabetes your risk of developing type 1 diabetes is higher than the general population.
The discovery of insulin is to this date the most important breakthrough in the treatment of diabetes. Before this type 1 diabetes was often fatal at a young age as the complication of ketoacidosis cannot be treated without using insulin. Type 1 diabetes must be treated with insulin unlike type 2 disease which may sometimes be managed with diet alone or by the use of tablets. Insulin cannot be taken as a tablet as it would be rapidly destroyed by the acid in the stomach. Insulin therapy involves regular injections into the layer of fat just beneath the skin.
Please refer to the page on Insulin therapy for more information on the use of insulin. Insulin injections are relatively painless and modern pen injection devices make the process of injection relatively easy. New blood glucose meters are capable of measuring blood glucose in 5 seconds which makes the task of monitoring relatively simple. New Insulin preparations in the past decade have also transformed the treatment of type 1 diabetes.
Dr Nishan Wijenaike, Consultant Physician
West Suffolk Hospitals Diabetes Service.
Revised: November 2007