Diabetes Medications and New Drugs

UprimaR (apomorphine hydrochloride)

What is UprimaR?

UprimaR is a new oral drug used for the treatment of erectile dysfunction. It contains a chemical known as apomorphine which is also used as a treatment for Parkinson’s disease.

How does it work?

UprimaR works on a part of the brain called the hypothalamus. It stimulates receptors in the brain which influence the process of having an erection. By stimulating these receptors erections occur more easily.

Is it effective?

The efficacy of UprimaR is thought to be comparable with Viagra.

What are the differences between Uprima and other treatments ?

UprimaR dissolves under the tongue and is absorbed directly into the blood stream. This is thought to result in a faster onset of action.

The other important difference between UprimaR and ViagraR is that UprimaR may produce an erection without any sexual stimulation.

What is the dosage?

UprimaR is available in two strengths 2 mg and 3 mg. Most men would be started on a 2mg dose which may be increased to 3 mg if necessary by your doctor. Take the tablet 20 minutes before sexual activity. You should take a small amount of water before taking UprimaR. The tablet is then left to dissolve under the tongue, a process which takes about five minutes. Do not take more than 2 - 3 mg in an 8 hour period.

How soon does it work?

The average time to onset of an erection is 10-15 minutes.

How often can I use it?

This drug may be taken every day if you wish.

Can I use it with ViagraR?

This is not recommended.

What are the side effects?

  • Nausea and dizziness (usually mild, more likely with higher doses)
  • Headache

How do I obtain a prescription?

UprimaR is available on the NHS. See your GP or Diabetes Specialist for a prescription.

Can I buy it on the internet?

The internet is awash with sites offering ViagraR and UprimaR. Only use this medication on the advice of your doctor who will give you a prescription which can be filled at any chemist. If you do not wish to obtain your supply from a chemist, there are sites in the UK which supply NHS prescriptions online.


Dr Nishan Wijenaike
Consultant Diabetologist
West Suffolk Diabetes Service
November 2003


Glucose Lowering drugs

Drugs for blood pressure

Cholesterol and other lipid lowering drugs

Drugs to lower cardiovascular risk

Drugs for neuropathic pain

Drugs which help weight loss

Drugs for erectile dysfunction

Drugs for Type 2 diabetes